Description

Cetuximab is a recombinant chimeric monoclonal antibody that specifically binds to the epidermal growth factor receptor (EGFR), inhibiting its signaling pathway. This targeted therapeutic action is critical for the treatment of certain metastatic cancers, offering a precision approach to oncology. It is primarily utilized in the biopharmaceutical industry for the formulation of advanced cancer therapeutics, specifically for colorectal and head and neck cancers.

Application

• Oncological Therapeutics: Primary use in the treatment of metastatic colorectal cancer and squamous cell carcinoma of the head and neck.
• Biopharmaceutical Research: Serves as a key reference standard and active ingredient in R&D for novel EGFR-targeting therapies.
• Clinical Manufacturing: Used in the GMP-compliant production of injectable biologic drug products.
• Combinatorial Therapy: Employed in combination with radiation therapy or other chemotherapeutic agents to enhance treatment efficacy.
• Diagnostic Development: Utilized in the development of companion diagnostic tests to identify patients with EGFR-expressing tumors.

Basic Information

Product Name	Cetuximab
CAS No.	205923-56-4
Molecular Formula	C6484H10042N1732O2013S36
Molecular Weight	Approx. 145.8 kDa
Synonyms	Cetuximab; IMC-C225; Erbitux; Anti-EGFR Monoclonal Antibody; Chimeric 225; C225; MOAB C225; EGFR Blocking Antibody
EINECS	Contact for details

Quality Control

Our Cetuximab is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing including purity analysis by SE-HPLC, potency assays, and endotoxin testing to ensure it meets rigorous standards for biopharmaceutical use. Certificates of Analysis (COA) detailing identity, purity, activity, and safety profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive). For long-term stability, store lyophilized material at 2-8°C. Reconstituted solutions should be used immediately or stored according to validated protocols. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear to slightly opalescent solution
Identification (HPLC/LC-MS)	Conforms to reference standard
Purity (SE-HPLC)	≥ 98.0% (Monomer)
Protein Content (UV-A280)	As per COA
Potency (Cell-based ELISA/Bioassay)	90% - 110% of reference
Endotoxin	< 1.0 EU/mg
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.