Description

Orexin B (Human) is a potent neuropeptide hormone, also known as hypocretin-2, that plays a critical role in regulating arousal, wakefulness, and appetite. This high-purity peptide is essential for advanced research in neurobiology and the development of therapeutic agents targeting sleep disorders and metabolic conditions. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on central nervous system (CNS) drug discovery and metabolic studies.

Application

• Neuroscience Research: Fundamental studies on sleep/wake cycles, narcolepsy, and arousal mechanisms.
• Pharmacological Development: As a reference standard or active pharmaceutical ingredient (API) in pre-clinical trials for insomnia and sleep disorder therapeutics.
• Metabolic Disorder Studies: Investigation of its role in energy homeostasis, feeding behavior, and potential treatments for obesity.
• Cell Signaling & Receptor Binding Assays: Used in vitro to study Orexin receptor (OX2R) activation and downstream signaling pathways.
• Biochemical Tool: As a critical reagent in assay development and high-throughput screening (HTS) for drug discovery programs.
• Academic & Clinical Research: Supporting basic science and translational research in neurology and endocrinology.

Basic Information

Product Name	Orexin B (Human)
CAS No.	205640-91-1
Molecular Formula	C₁₀₈H₁₆₉N₃₅O₅₀S₄
Molecular Weight	2856.2 g/mol
Synonyms	Hypocretin-2; Human Orexin B; Orexin-B; OXB; Hypocretin 2 (human); Prepro-orexin (130-178) (human); Orexin B, human; Orexin-B peptide
EINECS	Contact for details

Quality Control

Our Orexin B (Human) is manufactured under strict quality systems suitable for research and development applications. Each batch is subjected to rigorous analytical testing, including HPLC for purity and Mass Spectrometry for identity confirmation, to ensure batch-to-batch consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing purity, content, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.