Description

Fmoc-L-4,4'-Biphenylalanine CAS NO 205526-38-1 is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing the rigid, hydrophobic, and aromatic biphenyl moiety into peptide chains, enabling the development of novel structures with tailored properties. It is an essential building block for researchers and manufacturers in pharmaceutical R&D, particularly for creating peptide-based therapeutics, diagnostic agents, and materials science applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tert-butyl strategy, used to incorporate the biphenylalanine residue into peptide sequences.
• Pharmaceutical Research: Synthesis of peptide drug candidates targeting protein-protein interactions, where the rigid biphenyl group is used as a molecular scaffold or to enhance binding affinity.
• Peptidomimetics Development: Creation of peptide-like molecules with improved metabolic stability and bioavailability for therapeutic applications.
• Chemical Biology Probes: Construction of labeled or modified peptides for studying biological mechanisms and pathways.
• Materials Science: Synthesis of functional peptides for creating novel biomaterials, hydrogels, or surface coatings.
• Academic & Industrial R&D: Fundamental research in organic chemistry, medicinal chemistry, and peptide science.

Basic Information

Product Name	Fmoc-L-4,4'-Biphenylalanine
CAS No.	205526-38-1
Molecular Formula	C30H25NO4
Molecular Weight	463.52 g/mol
Synonyms	Fmoc-Bip(4,4')-OH; Fmoc-4,4'-Biphenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4,4'-biphenyl-L-alanine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-[1,1'-biphenyl]-4-ylpropanoic acid; Fmoc-L-Bip(4,4')-OH; Fmoc-Biphenylalanine; N-Fmoc-4,4'-biphenyl-L-alanine; Fmoc-4-Biphenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-L-4,4'-Biphenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.