Description

Fmoc-D-4-Iodophenylalanine CAS NO 205526-29-0 is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected α-amino group and an iodinated aromatic side chain. This compound is a critical building block for the solid-phase peptide synthesis (SPPS) of peptides designed for pharmaceutical research and drug discovery. It is essential for researchers and manufacturers in the fields of medicinal chemistry, bioconjugation, and the development of peptide-based therapeutics, particularly those requiring site-specific modification, radiolabeling precursors, or the introduction of heavy atoms for structural studies.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides containing iodophenylalanine residues.
• Pharmaceutical Intermediates: Serves as a crucial intermediate in the research and development of novel peptide drugs and targeted therapeutics.
• Bioconjugation and Probe Development: The iodine atom on the phenyl ring provides a handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Sonogashira) for attaching fluorescent tags, biotin, or other probes.
• Radiolabeling Precursors: The iodine-127 variant can be used as a precursor for radioiodination (e.g., with I-125 or I-131) to create radiolabeled peptides for diagnostic imaging or radiotherapy research.
• Structural Biology: Incorporation into peptides for X-ray crystallography studies, where the heavy iodine atom can aid in phasing.
• Chemical Biology Research: Used to study protein-protein interactions, receptor-ligand binding, and to create peptide libraries for screening.

Basic Information

Product Name	Fmoc-D-4-Iodophenylalanine
CAS No.	205526-29-0
Molecular Formula	C24H20INO4
Molecular Weight	513.32 g/mol
Synonyms	Fmoc-D-4-Iodo-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-iodo-D-phenylalanine; Fmoc-D-Phe(4-I)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-iodophenyl)propanoic acid; N-Fmoc-4-iodo-D-phenylalanine; Fmoc-4-I-D-Phe-OH; D-4-Iodophenylalanine, N-Fmoc derivative; Fmoc-D-p-iodophenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-D-4-Iodophenylalanine is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive research and development applications. Each batch is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided to guarantee compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.