Description

Fmoc-D-3-Trifluoromethylphe CAS NO 205526-28-9 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is a critical building block for the development of novel pharmaceuticals and bioactive peptides, offering enhanced metabolic stability and binding affinity through the incorporation of a trifluoromethyl group. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for creating peptide-based therapeutics targeting central nervous system disorders, metabolic diseases, and oncology.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptide sequences.
• Pharmaceutical Research & Development: For the discovery and optimization of peptide drug candidates with improved pharmacokinetic properties.
• Peptidomimetic Design: Incorporation into peptide backbones to enhance resistance to enzymatic degradation and modulate lipophilicity.
• Chemical Biology Probes: Synthesis of labeled or modified peptides used in studying protein-protein interactions and cellular pathways.
• Agrochemical Research: Development of novel peptide-based bioactive compounds for crop protection.
• Material Science: Building block for the creation of specialized peptide-based polymers and biomaterials.

Basic Information

Product Name	Fmoc-D-3-Trifluoromethylphe
CAS No.	205526-28-9
Molecular Formula	C₂₅H₂₀F₃NO₄
Molecular Weight	455.43 g/mol
Synonyms	Fmoc-3-(Trifluoromethyl)-D-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(trifluoromethyl)-D-phenylalanine; Fmoc-D-Phe(3-CF3)-OH; Fmoc-3-CF3-D-Phe-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-(trifluoromethyl)phenyl)propanoic acid; Fmoc-D-3-TfmPhe; Fmoc-D-Phe(3-CF₃)-OH
EINECS	Contact for details

Quality Control

Every batch of Fmoc-D-3-Trifluoromethylphe is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (HPLC), chiral purity, and residual solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.