Description

Fmoc-D-3,5-Difluorophe CAS NO 205526-25-6 is a high-purity, non-natural amino acid derivative featuring a D-configuration and a 3,5-difluorophenyl side chain, protected by a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in modern solid-phase peptide synthesis (SPPS), enabling the precise incorporation of fluorinated aromatic residues to modulate the physicochemical and biological properties of synthetic peptides. It is essential for researchers and manufacturers in pharmaceutical R&D, bioconjugation, and the development of peptide-based therapeutics, diagnostics, and materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of complex peptide sequences.
• Pharmaceutical Research: Used to synthesize peptide drug candidates where fluorination enhances metabolic stability, bioavailability, and binding affinity to target proteins.
• Peptidomimetics & Constrained Peptides: Incorporation of the difluorophenyl group aids in creating stable secondary structures and mimicking natural protein folds.
• Bioconjugation & Probe Development: Serves as a precursor for labeling peptides with fluorophores, radionuclides, or other functional tags for imaging and diagnostic applications.
• Chemical Biology & Proteomics: Employed in the study of protein-protein interactions and enzyme activity through the design of specific peptide substrates or inhibitors.
• Material Science: Used to create fluorinated peptide polymers and surfaces with unique hydrophobic and self-assembly properties.

Basic Information

Product Name	Fmoc-D-3,5-Difluorophe
CAS No.	205526-25-6
Molecular Formula	C24H19F2NO4
Molecular Weight	423.41 g/mol
Synonyms	Fmoc-D-3,5-difluorophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,5-difluoro-D-phenylalanine; (2R)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(3,5-difluorophenyl)propanoic acid; Fmoc-3,5-Difluoro-D-Phe-OH; Fmoc-D-F2Phe-OH; N-Fmoc-3,5-difluoro-D-phenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-D-3,5-Difluorophe is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.