Description

(1S,2S)-(-)-1,2-Diaminocyclohexane-N,N'-Bis(2-Diphenylphosphino-1-Naphthoyl) is a sophisticated, chiral bidentate ligand widely used in asymmetric catalysis. This compound matters because it enables highly enantioselective transformations, which are critical for producing single-isomer pharmaceuticals and fine chemicals with superior purity and efficacy. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control in their synthetic routes.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, a cornerstone reaction in chiral API synthesis.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in complex drug molecules, including antibiotics, antivirals, and cardiovascular agents.
• Agrochemical Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and pesticides for enhanced activity and environmental safety.
• Asymmetric C-C Bond Formation: Facilitates key cross-coupling and addition reactions with high stereoselectivity for building complex molecular architectures.
• Catalyst Screening & Development: A valuable tool in R&D for discovering and optimizing new catalytic processes in academic and industrial laboratories.
• Fine Chemical Manufacturing: Enables the production of high-value chiral flavors, fragrances, and electronic chemicals.

Basic Information

Item	Details
Product Name	(1S,2S)-(-)-1,2-Diaminocyclohexane-N,N'-Bis(2-Diphenylphosphino-1-Naphthoyl)
CAS No.	205495-66-5
Molecular Formula	C58H48N2O2P2
Molecular Weight	891.0 g/mol
Synonyms	(1S,2S)-(-)-1,2-DACH-NAP; (S,S)-DACH-NAP; (S,S)-(-)-1,2-Diaminocyclohexane-N,N'-bis(2-diphenylphosphino-1-naphthoyl); (S,S)-DACH-Naphthoyl; (1S,2S)-1,2-Diaminocyclohexane-N,N'-bis(2-(diphenylphosphino)-1-naphthoate); (S,S)-DACH-NAP Ligand; (S,S)-DACH-NAP Phosphine Ligand; (S,S)-DACH-NAP Catalyst
EINECS	Contact for details

Quality Control

Our (1S,2S)-(-)-1,2-Diaminocyclohexane-N,N'-Bis(2-Diphenylphosphino-1-Naphthoyl) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting research and process development standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere to ensure long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.