Description

Boc-D-3,4,5-Trifluorophenylalanine is a high-purity, non-natural amino acid derivative extensively used in advanced pharmaceutical research and development. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry. It is essential for medicinal chemists and researchers in the pharmaceutical and biotechnology sectors developing novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel peptide-based drugs and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a trifluoromethylphenylalanine residue, enhancing peptide stability and lipophilicity.
• Medicinal Chemistry Research: Serves as a building block for creating focused libraries of compounds for structure-activity relationship (SAR) studies and high-throughput screening.
• API Development: Integral in the research and process development stages for new Active Pharmaceutical Ingredients, especially in oncology and metabolic disease research.
• Bioconjugation: The Boc-protected amino acid can be used in the preparation of labeled peptides or peptide-drug conjugates for diagnostic and therapeutic applications.

Basic Information

Product Name	Boc-D-3,4,5-Trifluorophenylalanine
CAS No.	205445-55-2
Molecular Formula	C₁₄H₁₆F₃NO₄
Molecular Weight	319.28 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-3-(3,4,5-trifluorophenyl)propanoic acid; Boc-D-3,4,5-F₃-Phe-OH; N-(tert-Butoxycarbonyl)-3,4,5-trifluoro-D-phenylalanine; Boc-D-(3,4,5-Trifluoro)Phe; N-Boc-3,4,5-trifluoro-D-phenylalanine; tert-Butyloxycarbonyl-D-3,4,5-trifluorophenylalanine; BOC-D-3,4,5-TRIFLUOROPHENYLALANINE
EINECS	Contact for details

Quality Control

Our Boc-D-3,4,5-Trifluorophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.