Description

Js-K is a nitric oxide (NO)-releasing prodrug specifically designed for targeted cancer therapy research. This compound matters as a key pharmacological tool for investigating novel mechanisms of inducing apoptosis in cancer cells, particularly those resistant to conventional treatments. Researchers in oncology, medicinal chemistry, and pharmaceutical development need it to study its selective activation by glutathione S-transferase (GST) enzymes and its potential as a chemotherapeutic agent.

Application

• Anticancer Research: Primary tool for studying nitric oxide-mediated apoptosis in various cancer cell lines, including hepatic, pancreatic, and colon cancers.
• Mechanistic Studies: Used to investigate the role of glutathione S-transferase (GST) enzymes in prodrug activation and targeted drug delivery.
• Drug Discovery & Development: Serves as a lead compound or reference standard in the development of new GST-activated anticancer prodrugs.
• Biochemical Assays: Employed in in vitro and in vivo models to assess tumor response, pharmacokinetics, and toxicity profiles.
• Signal Transduction Research: Used to explore the downstream effects of nitric oxide release on cellular signaling pathways involved in cell death and survival.

Basic Information

Product Name	Js-K
CAS No.	205432-12-8
Molecular Formula	C15H12N4O6
Molecular Weight	344.28 g/mol
Synonyms	O2-(2,4-Dinitrophenyl) 1-[(4-Ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate; 1-[(4-Ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate 2-(2,4-Dinitrophenyl) Ester; JS-K; JSK; GST-activated NO prodrug; NO-releasing prodrug JS-K; PABA/NO analog
EINECS	Contact for details

Quality Control

Our Js-K is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.