Description

2-Trifluoromethyl-6-Chloro-5-Pyridineboric Acid is a high-value boronic acid derivative and a key synthetic intermediate in modern organic chemistry. Its primary commercial value lies in its role as a versatile building block for the Suzuki-Miyaura cross-coupling reaction, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Critical building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the central nervous system, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific trifluoromethyl-pyridine motifs for enhanced efficacy and environmental profile.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, liquid crystals, and metal-organic frameworks (MOFs) due to its unique electronic properties imparted by the trifluoromethyl and boronic acid groups.
• Cross-Coupling Reactions: A specialized reagent for Suzuki-Miyaura cross-coupling, facilitating the formation of carbon-carbon bonds between aryl halides and boronic acids under mild conditions.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and inhibitors for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical companies and CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	2-Trifluoromethyl-6-Chloro-5-Pyridineboric Acid
CAS No.	205240-63-7
Molecular Formula	C7H4BClF3NO2
Molecular Weight	225.37 g/mol
Synonyms	(6-Chloro-2-(trifluoromethyl)pyridin-3-yl)boronic Acid; 5-Borono-6-chloro-2-(trifluoromethyl)pyridine; 2-Trifluoromethyl-6-chloro-3-pyridineboronic Acid; 6-Chloro-2-trifluoromethylpyridine-3-boronic Acid; 3-Pyridineboronic acid, 6-chloro-2-(trifluoromethyl)-; 2-(Trifluoromethyl)-6-chloro-3-pyridinylboronic Acid; 205240-63-7; 6-Chloro-2-(trifluoromethyl)-3-pyridineboronic Acid
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethyl-6-Chloro-5-Pyridineboric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.