Description

(S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-(4-Methoxy-Phenyl)-Butyric Acid CAS NO 205182-66-7 is a high-purity, non-natural amino acid derivative featuring a side-chain protected methoxyphenyl group and an N-terminal Fmoc protecting group. This compound is a critical building block in the solid-phase synthesis of complex peptides and peptidomimetics, enabling the precise introduction of aromatic, hydrophobic character into peptide sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing therapeutic peptides targeting GPCRs and other protein-protein interactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical Research: Incorporation into novel peptide-based drug candidates to modulate bioavailability, receptor binding affinity, and metabolic stability.
• Peptidomimetic Design: Serves as a scaffold for creating non-peptide compounds that mimic the structure and function of bioactive peptides.
• Chemical Biology Probes: Used in the synthesis of labeled or modified peptides for studying enzyme mechanisms and cellular pathways.
• Antibody-Drug Conjugate (ADC) Linker/Payload Development: Potential use in constructing specialized linkers or as part of a cytotoxic peptide payload.
• Material Science: Exploration in creating bio-inspired polymers and self-assembling nanomaterials.

Basic Information

Item	Details
Product Name	(S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-(4-Methoxy-Phenyl)-Butyric Acid
CAS No.	205182-66-7
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-(S)-4-Methoxyphenylalanine; Fmoc-4-MeO-Phe-OH; Fmoc-O-methyl-L-tyrosine; Fmoc-L-4-Methoxyphenylalanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-4-(4-methoxyphenyl)butanoic acid; N-α-Fmoc-4-methoxy-L-phenylalanine; Fmoc-4-methoxy-L-Phe
EINECS	Contact for details

Quality Control

Our (S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-(4-Methoxy-Phenyl)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with pharmaceutical research and peptide synthesis standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to guarantee reproducible and reliable performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.