Description

Fmoc-L-Phe(4-Ch2-Oh) CAS NO 205128-76-3 is a protected amino acid derivative, specifically an Fmoc (9-fluorenylmethoxycarbonyl)-protected L-phenylalanine analog with a hydroxymethyl group at the para position. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and peptidomimetics. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require high-purity, structurally defined intermediates for creating novel therapeutic candidates and functional biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, sequential synthesis of custom peptides.
• Pharmaceutical Research: For the development of peptide-based drugs, hormone analogs, and diagnostic agents.
• Bioconjugation: The hydroxymethyl side chain provides a handle for further chemical modification and linkage to other molecules, carriers, or surfaces.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.
• Antibody-Drug Conjugate (ADC) Development: Serves as a specialized linker component or as part of the payload structure.
• Material Science: Incorporation into peptide-based polymers, hydrogels, and other bio-inspired materials.

Basic Information

Item	Detail
Product Name	Fmoc-L-Phe(4-Ch2-Oh)
CAS No.	205128-76-3
Molecular Formula	C25H23NO5
Molecular Weight	417.45 g/mol
Synonyms	Fmoc-L-4-(hydroxymethyl)phenylalanine; Fmoc-Tyr(Me)-OH (common mis-assignment check); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(hydroxymethyl)-L-phenylalanine; Fmoc-Phe(4-CH2OH)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-[4-(hydroxymethyl)phenyl]propanoic acid; Fmoc-L-Phenylalanine, 4-(hydroxymethyl)-; Fmoc-4-Hydroxymethyl-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-L-Phe(4-Ch2-Oh) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.