Description

Fmoc-Lys(Ddiv)-Oh is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically engineered to provide orthogonal protection for the lysine side chain, enabling the precise and sequential construction of complex peptides. It is a critical building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, allowing for the controlled incorporation of lysine.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting various diseases.
• Bioconjugation and Labeling: Serves as a precursor for introducing functional handles or labels onto peptides via the selectively deprotected lysine side chain.
• Combinatorial Chemistry: Employed in libraries for drug discovery to explore structure-activity relationships.
• Antibody-Drug Conjugate (ADC) Research: Facilitates the site-specific attachment of payloads to linker systems.
• Biochemical Research: Used in studying protein-protein interactions and enzyme mechanisms by creating custom peptide substrates or inhibitors.

Basic Information

Product Name	Fmoc-Lys(Ddiv)-Oh
CAS No.	204777-78-6
Molecular Formula	C₃₃H₄₅N₃O₇
Molecular Weight	595.73 g/mol
Synonyms	Fmoc-Lys(Ddiv)-OH; N-α-Fmoc-N-ε-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-lysine; Fmoc-Lys(ivDde)-OH (common alias); Fmoc-L-lysine(N-ivDde)-OH; (2S)-6-[[2-(3,5-Dimethyl-2,6-dioxo-4-cyclohexen-1-ylidene)-3-methylbutyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid; N-α-(9-Fluorenylmethyloxycarbonyl)-N-ε-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl)-L-lysine; Fmoc-Lys(ivDde)-OH (alternate spelling); Fmoc-Lys(ivDde)
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(Ddiv)-Oh is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and cGMP manufacturing. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for peptide synthesis building blocks, ensuring reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This material is hygroscopic (moisture-sensitive) and should be kept under dry, inert conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.