Description

Fmoc-L-Phe(4-Coch3) CAS NO 204716-07-4 is a protected derivative of the amino acid phenylalanine, featuring an Fmoc (9-fluorenylmethoxycarbonyl) protecting group on the amine and an acetyl-protected hydroxyl group on the aromatic ring. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and peptidomimetics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, diagnostic agents, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the automated, stepwise synthesis of custom peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Peptidomimetic Design: Serves as a precursor for creating modified peptides with enhanced stability, bioavailability, or receptor affinity.
• Combinatorial Chemistry Libraries: Employed to generate diverse arrays of compounds for high-throughput screening against biological targets.
• Bioconjugation and Probe Development: The reactive handles allow for the site-specific incorporation of labels or linkers into peptide sequences.
• Academic and Industrial Research: A fundamental reagent for studying protein structure-function relationships and biochemical pathways.

Basic Information

Product Name	Fmoc-L-Phe(4-Coch3)
CAS No.	204716-07-4
Molecular Formula	C₂₇H₂₅NO₅
Molecular Weight	443.49 g/mol
Synonyms	Fmoc-O-acetyl-L-tyrosine; Fmoc-L-Tyr(Ac)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-acetyl-L-tyrosine; Fmoc-L-tyrosine(O-acetyl); Fmoc-Tyr(Ac)-OH; Nα-Fmoc-O-acetyl-L-tyrosine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-[4-(acetyloxy)phenyl]propanoic acid; Fmoc-L-Phe(4-Coch3)
EINECS	Contact for details

Quality Control

Our Fmoc-L-Phe(4-Coch3) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR for structural verification. We provide Certificates of Analysis (COA) with each shipment, detailing all relevant specifications to ensure the material meets the stringent requirements for peptide synthesis and pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.