Description

Boc-3,5-Dibromo-D-Tyr-Oh is a protected, halogenated derivative of the non-natural D-isomer of the amino acid tyrosine, serving as a crucial chiral building block in advanced organic synthesis. This compound is specifically engineered to introduce sterically hindered, brominated aromatic motifs into peptide chains and complex molecules, enabling precise structural modifications. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel drug candidates, peptide mimetics, and specialized biochemical probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for oncology and metabolic disease targets.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate brominated tyrosine residues, which can be further functionalized via cross-coupling reactions.
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes and affinity tags to study protein function and interactions.
• Material Science Research: Acts as a precursor for designing novel aromatic polymers and advanced organic materials with specific optoelectronic properties.
• Asymmetric Synthesis: Serves as a valuable starting material or auxiliary in catalytic asymmetric transformations to construct complex chiral architectures.

Basic Information

Product Name	Boc-3,5-Dibromo-D-Tyr-Oh
CAS No.	204692-75-1
Molecular Formula	C₁₄H₁₇Br₂NO₅
Molecular Weight	447.10 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-3,5-dibromo-D-tyrosine; Boc-D-Tyr(3,5-Br2)-OH; (2R)-2-[(tert-Butoxycarbonyl)amino]-3-(3,5-dibromo-4-hydroxyphenyl)propanoic acid; tert-Butyl (R)-(3-(3,5-dibromo-4-hydroxyphenyl)-1-carboxy-1-oxopropan-2-yl)carbamate; D-Boc-3,5-Dibromotyrosine; Boc-D-3,5-Dibromotyrosine; Boc-D-Tyr(Br2)-OH
EINECS	Contact for details

Quality Control

Our Boc-3,5-Dibromo-D-Tyr-Oh is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. A detailed Certificate of Analysis (COA) providing specifications for chiral purity (HPLC), assay, and related substances is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.