Description

Buspirone (D8) is a deuterium-labeled analog of the anxiolytic pharmaceutical compound buspirone, identified by CAS NO 204395-49-3. This stable isotope-labeled compound is a critical tool for quantitative bioanalytical research, enabling precise pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug development and analytical method validation.

Application

• As an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of buspirone in biological matrices.
• For conducting pharmacokinetic (PK) and bioavailability studies in preclinical and clinical research.
• In drug metabolism and disposition (DMPK) investigations to trace metabolic pathways and identify metabolites.
• Use in analytical method development and validation to ensure specificity, accuracy, and regulatory compliance (e.g., FDA, EMA).
• Supporting forensic and toxicological analysis for the definitive identification and measurement of buspirone.
• Application in quality control processes within pharmaceutical manufacturing for impurity profiling and reference standard qualification.

Basic Information

Product Name	Buspirone (D8)
CAS No.	204395-49-3
Molecular Formula	C21H23D8N5O2
Molecular Weight	~ 389.55 g/mol
Synonyms	8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione (D8); Buspirone-d8; Deuterated Buspirone; Buspirone (octadeuterated); MJ 9022-d8; Ansial-d8; Ansiced-d8; Buspar-d8
EINECS	Contact for details

Quality Control

Our Buspirone (D8) is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic purity (by MS), and residual solvents. We support research that demands reliable and traceable reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.