Description

(2S)-Pyrrolidine-2-Carbonitrile p-Toluene Sulfonate CAS NO 204387-54-2 is a high-purity chiral intermediate, specifically the p-toluenesulfonate salt of (2S)-pyrrolidine-2-carbonitrile. This compound is a critical building block in the synthesis of complex pharmaceutical molecules, offering a defined stereocenter essential for producing enantiomerically pure active ingredients. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing new drug candidates and advanced chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and other therapeutic areas.
• Asymmetric Synthesis: Serves as a precursor for chiral catalysts and ligands used in enantioselective chemical reactions.
• Protease Inhibitor Research: Used in the development and research of protease inhibitors, where the pyrrolidine scaffold is a common structural motif.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and agrochemicals.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry and process chemistry research in both academic and industrial laboratory settings.

Basic Information

Product Name	(2S)-Pyrrolidine-2-Carbonitrile p-Toluene Sulfonate
CAS No.	204387-54-2
Molecular Formula	C12H16N2O3S
Molecular Weight	268.33 g/mol
Synonyms	(2S)-2-Cyanopyrrolidine p-Toluenesulfonate; (S)-Pyrrolidine-2-carbonitrile 4-methylbenzenesulfonate; L-Prolinenitrile p-Toluenesulfonate Salt; (S)-(-)-2-Cyanopyrrolidine Tosylate; (2S)-1-(4-Methylphenyl)sulfonyl-2-pyrrolidinecarbonitrile; (S)-2-Cyanopyrrolidine Tosic Acid Salt; (2S)-2-Pyrrolidinecarbonitrile 4-methylbenzenesulfonic acid compound; Tosic Acid Salt of (S)-Prolinenitrile
EINECS	Contact for details

Quality Control

Our (2S)-Pyrrolidine-2-Carbonitrile p-Toluene Sulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade standards for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.