Description

(S)-Pyrrolidine-2-Carbonitrile CAS NO 204387-53-1 is a high-value, chiral non-natural amino acid derivative characterized by its pyrrolidine ring and nitrile functional group. This compound serves as a critical chiral building block and intermediate in the synthesis of complex, biologically active molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for applications in drug discovery and development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitors and other therapeutic agents.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in stereoselective chemical reactions to introduce the (S)-pyrrolidine scaffold.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel chiral ligands and organocatalysts used in enantioselective catalysis.
• Agrochemical Research: Employed in the synthesis of novel chiral compounds with potential herbicidal or insecticidal activity.
• Peptidomimetics: Incorporated into the design of peptide analogs and peptidomimetics to modulate biological activity and stability.
• Chemical Biology Probes: Used to create molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	(S)-Pyrrolidine-2-Carbonitrile
CAS No.	204387-53-1
Molecular Formula	C5H8N2
Molecular Weight	96.13 g/mol
Synonyms	(S)-2-Cyanopyrrolidine; (2S)-Pyrrolidine-2-carbonitrile; (S)-2-Pyrrolidinecarbonitrile; L-Prolinenitrile; (S)-Proline nitrile; (S)-1-Azabicyclo[3.1.0]hexane-2-carbonitrile (tautomer); (S)-Azetidine-2-carbonitrile (ring-contracted analog name)
EINECS	Contact for details

Quality Control

Our (S)-Pyrrolidine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications for identity, purity, and enantiomeric excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified for the specific grade.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Enantiomeric Excess)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.