Description

(S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-(4-Isopropyl-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring a fluorenylmethyloxycarbonyl (Fmoc) protecting group and a hydrophobic 4-isopropylphenyl side chain. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, enabling the precise control of stereochemistry and side-chain functionality. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, drug discovery, and the development of therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated, sequential assembly of custom peptides.
• Peptidomimetic Drug Discovery: Used to incorporate a bulky, hydrophobic aromatic moiety into peptide backbones to enhance binding affinity, metabolic stability, and membrane permeability.
• Pharmaceutical Intermediate: Serves as a chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Bioconjugation and Probe Development: Facilitates the site-specific labeling of peptides with fluorophores, biotin, or other functional tags for diagnostic and research applications.
• Academic and Industrial Research: Essential for studying protein-protein interactions, enzyme substrates/inhibitors, and structure-activity relationships (SAR) in medicinal chemistry.
• Combinatorial Chemistry Libraries: Used to create diverse compound libraries for high-throughput screening against biological targets.

Basic Information

Product Name	(S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-(4-Isopropyl-Phenyl)-Propionic Acid
CAS No.	204384-73-6
Molecular Formula	C27H27NO4
Molecular Weight	429.51 g/mol
Synonyms	Fmoc-(S)-4-isopropylphenylalanine; Fmoc-p-(iPr)-Phe-OH; Fmoc-4-isopropyl-L-phenylalanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-3-(4-isopropylphenyl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-isopropyl-L-phenylalanine; Nα-Fmoc-4-isopropyl-L-phenylalanine; Fmoc-L-Phe(4-iPr)-OH; N-Fmoc-4-isopropyl-L-phenylalanine
EINECS	Contact for details

Quality Control

Our production of (S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-(4-Isopropyl-Phenyl)-Propionic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research and pharmaceutical applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-enantiomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.