Description

(S)-3-(4-Ethyl-Phenyl)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Propionic Acid CAS NO 204384-72-5 is a high-purity, non-natural amino acid derivative featuring a chiral center and an Fmoc-protected amine group. This compound is a critical building block in modern pharmaceutical research and development, enabling the synthesis of complex, biologically active peptides and peptidomimetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for the development of targeted therapeutics and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a key monomer for the sequential assembly of custom peptides on resin supports.
• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) for investigational new drugs, especially those targeting specific protein-protein interactions.
• Peptidomimetic Drug Design: Used to incorporate non-natural, side-chain modified amino acids into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• Bioconjugation and Labeling: The carboxylic acid and protected amine functionalities allow for site-specific conjugation to other molecules, dyes, or solid surfaces for diagnostic and research applications.
• Chemical Biology Research: Employed in the study of enzyme mechanisms, receptor-ligand interactions, and the development of novel biochemical probes.
• Material Science: Can be used to synthesize peptide-based polymers or hydrogels with tailored properties for biomedical engineering.

Basic Information

Product Name	(S)-3-(4-Ethyl-Phenyl)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Propionic Acid
CAS No.	204384-72-5
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	Fmoc-(S)-3-(4-Ethylphenyl)alanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-ethylphenyl)propanoic acid; Fmoc-3-(4-Ethyl-Phe)-OH; N-α-Fmoc-3-(4-ethylphenyl)-L-alanine; N-Fmoc-3-(4-ethylphenyl)-L-alanine; Fmoc-L-3-(4-Ethylphenyl)alanine; Fmoc-4-Ethyl-L-phenylalanine; Fmoc-3-(p-Ethylphenyl)-L-alanine
EINECS	Contact for details

Quality Control

Our (S)-3-(4-Ethyl-Phenyl)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Propionic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. All products undergo rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.