Description

Fmoc-L-1,2,3,4-Tetrahydronorharman-3-Carboxylic Acid is a sophisticated, non-proteinogenic amino acid derivative featuring the Fmoc-protected tetrahydronorharman scaffold. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering unique structural and pharmacological properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing novel central nervous system (CNS) and oncology therapeutics. The high purity and reliable synthesis of this advanced intermediate are essential for ensuring the success of downstream medicinal chemistry and peptide synthesis programs.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key, protected amino acid building block for the controlled assembly of complex peptide sequences.
• Medicinal Chemistry & Drug Discovery: Used in the design and synthesis of novel drug candidates, especially those targeting neurological receptors and enzymes.
• Peptidomimetic Development: Incorporated into peptide-like molecules to enhance stability, bioavailability, and binding affinity.
• Chemical Biology Research: Employed as a molecular probe to study protein-protein interactions and enzyme mechanisms.
• Pharmaceutical Intermediate: Acts as a precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) with specific stereochemical requirements.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and peptide science.

Basic Information

Product Name	Fmoc-L-1,2,3,4-Tetrahydronorharman-3-Carboxylic Acid
CAS No.	204322-23-6
Molecular Formula	C27H24N2O4
Molecular Weight	440.49 g/mol
Synonyms	Fmoc-Tetrahydronorharman-3-COOH; (S)-9H-Fluoren-9-ylmethyl (1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-3-yl)carbamate; Fmoc-L-β-Carboline-3-carboxylic acid (tetrahydro); Fmoc-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic acid; Fmoc-Tic(THβC)-OH; Fmoc-L-Tic(THβC)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our Fmoc-L-1,2,3,4-Tetrahydronorharman-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive spectroscopic identification (NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports critical applications in pharmaceutical R&D where consistency and purity are paramount.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be sealed under an inert atmosphere (argon or nitrogen) after each use and allowed to equilibrate to room temperature before opening to prevent condensation. Store in a cool, dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.