Description

L-Proline, 1-Benzoyl-4-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (4S)- (9Ci) CAS NO 204321-85-7 is a sophisticated, stereochemically defined amino acid derivative designed for advanced synthetic applications. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering precise control over molecular architecture. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing novel therapeutic agents and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected proline derivative for the controlled incorporation of proline residues into peptide chains, particularly in Fmoc-based strategies.
• Peptidomimetic Drug Discovery: Serves as a crucial intermediate in the design and synthesis of non-peptide molecules that mimic the structure and function of natural peptides for enhanced stability and bioavailability.
• Pharmaceutical Intermediate: Used in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting a range of conditions, including metabolic and neurological disorders.
• Bioconjugation and Probe Development: Acts as a functionalized linker or spacer molecule for attaching labels, tags, or other functional groups to peptides and proteins in biochemical research.
• Academic and Industrial Research: A valuable reagent for methodological development in organic chemistry and for exploring new routes in asymmetric synthesis.

Basic Information

Product Name	L-Proline, 1-Benzoyl-4-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (4S)- (9Ci)
CAS No.	204321-85-7
Molecular Formula	C26H22N2O5
Molecular Weight	442.47 g/mol
Synonyms	Fmoc-4-Amino-L-proline(Bzl); 1-Benzoyl-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-L-proline; (2S,4S)-1-Benzoyl-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}pyrrolidine-2-carboxylic acid; Fmoc-Aze(Bzl)-OH; Fmoc-4-NH2-Pro(Bzl)-OH; Nα-Fmoc-Nδ-benzoyl-L-2,4-diaminobutyric acid (cyclic proline analog); 4-[(Fmoc-amino)]-1-(benzoyl)-L-proline
EINECS	Contact for details

Quality Control

Our production of this high-purity building block adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic workflows. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as chiral purity, chemical purity, and residual solvent content. While typically supplied as a research-grade material, specifications can be aligned with cGMP guidelines for advanced development stages upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This compound is hygroscopic (moisture-sensitive); containers should be allowed to reach room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.