Description

Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid is a high-purity, non-natural amino acid derivative used as a critical building block in advanced organic synthesis. This compound matters because it provides a chiral, protected scaffold essential for constructing complex peptide-based pharmaceuticals and bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of peptide therapeutics, peptidomimetics, and combinatorial chemistry libraries.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the automated synthesis of peptides containing the constrained tetrahydroisoquinoline (Tic) backbone.
• Peptidomimetic Drug Discovery: Incorporation into drug candidates to enhance metabolic stability, receptor selectivity, and conformational rigidity.
• Combinatorial Chemistry: Serving as a key chiral component in the generation of diverse compound libraries for high-throughput screening.
• API Intermediate Manufacturing: Use in the multi-step synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Bioconjugation and Probe Development: Functionalization of biomolecules or materials with the tetrahydroisoquinoline carboxylic acid moiety for research applications.

Basic Information

Product Name	Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid
CAS No.	204317-98-6
Molecular Formula	C26H23NO4
Molecular Weight	413.47 g/mol
Synonyms	Fmoc-D-Tic-OH; (R)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; Fmoc-(R)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid; Fmoc-D-1,2,3,4-Tetrahydro-isoquinoline-1-carboxylic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; Fmoc-D-Tetrahydroisoquinolinecarboxylic Acid; Fmoc-D-Tic; (R)-Fmoc-Tic-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and specific impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.