Description

Fmoc-D-4-Methylphe CAS NO 204260-38-8 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of the D-isomer of 4-methylphenylalanine into peptide chains, enabling the creation of novel peptides with enhanced stability and specific biological activity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in developing therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical Research: Incorporation into peptide-based drug candidates to modulate pharmacokinetic properties and receptor binding.
• Bioconjugation: Used in the synthesis of peptide tags and linkers for protein labeling and immobilization.
• Antibody-Drug Conjugate (ADC) Development: A component in the synthesis of peptide linkers for targeted drug delivery systems.
• Chemical Biology Probes: Synthesis of labeled or modified peptides for studying enzyme mechanisms and protein-protein interactions.
• Material Science: Building block for peptide-based polymers and biomaterials with tailored properties.

Basic Information

Product Name	Fmoc-D-4-Methylphe
CAS No.	204260-38-8
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	Fmoc-D-4-methylphenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methyl-D-phenylalanine; Fmoc-4-Me-D-Phe-OH; Fmoc-D-p-methylphenylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(p-tolyl)propanoic acid; N-Fmoc-4-methyl-D-phenylalanine; Fmoc-D-4-MePhe; Fmoc-D-Tyr(Me)-OH (common alias, though not strictly correct)
EINECS	Contact for details

Quality Control

Our Fmoc-D-4-Methylphe is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Optical Rotation	Contact for details
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.