Description

4-[2’-(7’’-Deazaguanine)Ethyl]Benzoic Acid n-Hydroxysuccinimide Ester is a high-purity, heterocyclic building block designed for advanced bioconjugation and labeling applications. This compound is critical for researchers and manufacturers requiring precise, covalent attachment of biomolecules, such as oligonucleotides or proteins, to solid supports or other functional moieties. It is primarily utilized in the development of diagnostic assays, targeted drug delivery systems, and advanced materials within the pharmaceutical, biotechnology, and life science research sectors.

Application

• Bioconjugation Reagent: For the covalent coupling of deazaguanine-modified oligonucleotides to carrier proteins, polymers, or surfaces.
• Diagnostic Probe Synthesis: A key intermediate in the production of labeled probes for fluorescence in situ hybridization (FISH) and other molecular diagnostic techniques.
• Drug-Linker Conjugate: Used in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutic constructs.
• Surface Functionalization: Enables the modification of nanoparticles, microarrays, and biosensor surfaces with specific biomolecular recognition elements.
• Nucleic Acid Labeling: Facilitates the site-specific introduction of reporter groups (e.g., fluorophores, haptens) into synthetic DNA or RNA strands.
• Chemical Biology Research: A valuable tool for studying nucleic acid-protein interactions and cellular processes through bioorthogonal labeling strategies.

Basic Information

Product Name	4-[2’-(7’’-Deazaguanine)Ethyl]Benzoic Acid n-Hydroxysuccinimide Ester
CAS No.	204257-65-8
Molecular Formula	C20H18N6O5
Molecular Weight	422.40 g/mol
Synonyms	7-Deaza-2'-deoxyguanosine NHS ester; 4-[2-(7-Deazaguanin-9-yl)ethyl]benzoic acid N-hydroxysuccinimide ester; 7-Deazaguanine C2-EDB NHS ester; p-[2-(7-Deazaguanin-9-yl)ethyl]benzoic acid N-succinimidyl ester; NHS ester of 7-deazaguanine EDB benzoic acid; 4-(2-(7H-Pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl)benzoic acid N-hydroxysuccinimide ester; EDB-7-deazaguanine-NHS
EINECS	Contact for details

Quality Control

Our 4-[2’-(7’’-Deazaguanine)Ethyl]Benzoic Acid n-Hydroxysuccinimide Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.