Description

Fmoc-D-Asp-Oall CAS NO 204246-17-3 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically engineered to facilitate the controlled incorporation of D-aspartic acid into peptide chains, enabling the research and development of novel peptides with enhanced stability and biological activity. It is a critical building block for pharmaceutical researchers, medicinal chemists, and biotech companies engaged in the synthesis of therapeutic peptides, peptidomimetics, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the Fmoc/tBu strategy, enabling the sequential assembly of peptide chains on resin.
• Pharmaceutical R&D: Used in the research and development of therapeutic peptides, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Peptidomimetic Design: Facilitates the creation of non-natural peptide analogs with improved metabolic stability and receptor binding affinity by incorporating the D-aspartic acid stereoisomer.
• Bioconjugation and Labeling: The orthogonal protecting groups (Fmoc on the α-amine and All on the side chain) allow for selective deprotection, useful for site-specific modifications and linker attachments.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Academic Research: A fundamental reagent in university and institutional labs studying protein structure-function relationships, enzyme substrates, and signal transduction pathways.

Basic Information

Product Name	Fmoc-D-Asp-Oall
CAS No.	204246-17-3
Molecular Formula	C22H21NO6
Molecular Weight	395.41 g/mol
Synonyms	Fmoc-D-aspartic acid β-allyl ester; N-(9-Fluorenylmethoxycarbonyl)-D-aspartic acid 4-allyl ester; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]butanedioic acid 4-allyl ester; Fmoc-D-Asp(All)-OH; Fmoc-D-Asp(OAll)-OH; Fmoc-D-Asp(All); N-Fmoc-D-aspartic acid β-allyl ester; Allyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-aspartate
EINECS	Contact for details

Quality Control

Our Fmoc-D-Asp-Oall is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and chiral analysis to confirm stereochemical integrity. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions, moisture, or light should be avoided to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.