Description

Prasugrel Metabolite R-138727 is a key active metabolite of the antiplatelet drug Prasugrel, identified by CAS NO 204204-73-9. This compound is of critical importance for pharmaceutical research and development, serving as a primary reference standard for bioanalytical studies, pharmacokinetic profiling, and drug metabolism investigations. It is essential for analytical laboratories, pharmaceutical manufacturers, and contract research organizations (CROs) focused on cardiovascular drug development, quality control, and regulatory compliance.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of Prasugrel's active metabolite in biological matrices during clinical and non-clinical studies.
• Bioanalytical Method Development & Validation: Critical for developing and validating sensitive LC-MS/MS or HPLC methods to assess drug exposure and metabolism.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Used to establish correlation between plasma concentration levels and antiplatelet effect in research.
• Impurity Profiling and Characterization: Serves as a marker for related substance testing and stability studies of Prasugrel drug substance and finished dosage forms.
• DMPK (Drug Metabolism and Pharmacokinetics) Research: Fundamental for in vitro and in vivo studies to understand metabolic pathways and clearance mechanisms.
• Regulatory Submissions: Provides essential data to support Investigational New Drug (IND) and New Drug Application (NDA) filings with agencies like the FDA and EMA.

Basic Information

Product Name	Prasugrel Metabolite R-138727
CAS No.	204204-73-9
Molecular Formula	C14H16FNO3S
Molecular Weight	297.35 g/mol
Synonyms	R-138727; (R)-2-[2-(Acetylsulfanyl)-1-cyclopropyl-2-(2-fluorophenyl)ethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl acetate; Prasugrel Active Metabolite; PSI-697; (5R)-5-(2-Cyclopropyl-1-(2-fluorophenyl)-2-((S)-sulfanylacetyl)ethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl acetate; Active Metabolite of Prasugrel
EINECS	Contact for details

Quality Control

Our Prasugrel Metabolite R-138727 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (NMR, IR, MS), purity determination by HPLC, and control of specified impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with in-house specifications suitable for use as a high-purity reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.