Description

n-Boc-L-Isoleucine Hemihydrate is a protected amino acid derivative essential for peptide synthesis. This high-purity building block is critical for ensuring the fidelity and yield of complex peptide sequences in pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for the production of peptide-based drugs and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of peptides, particularly where the isoleucine side chain requires protection.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for constructing peptide fragments in solution.
• Pharmaceutical Intermediates: Serves as a crucial building block in the research and production of therapeutic peptides and peptidomimetics.
• Bioconjugation and Labeling: The Boc-protected amino group allows for selective deprotection and subsequent conjugation with other molecules, such as fluorescent dyes or polymers.
• Chemical Biology Research: Employed in the synthesis of custom peptides for studying protein-protein interactions, enzyme activity, and cellular processes.
• Combinatorial Chemistry Libraries: Used to generate diverse arrays of peptide-like compounds for high-throughput screening in drug discovery.

Basic Information

Product Name	n-Boc-L-Isoleucine Hemihydrate
CAS No.	204138-23-8
Molecular Formula	C11H21NO4 · ½ H2O
Molecular Weight	246.29 g/mol (anhydrous basis)
Synonyms	N-(tert-Butoxycarbonyl)-L-isoleucine hemihydrate; Boc-Ile-OH · ½ H2O; (2S,3S)-2-[(tert-Butoxycarbonyl)amino]-3-methylpentanoic acid hemihydrate; tert-Butyloxycarbonyl-L-isoleucine hemihydrate; Boc-L-Isoleucine hemihydrate; N-Boc-L-Isoleucine 0.5 hydrate; N-α-Boc-L-Isoleucine hemihydrate
EINECS	Contact for details

Quality Control

Our n-Boc-L-Isoleucine Hemihydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identification tests to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with full batch traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]	Contact for details
Water Content (KF)	3.0 - 5.0% (Theoretical for hemihydrate: ~3.66%)
Chiral Purity (HPLC)	≥99.0%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.