Description

Melan-A/Mart-1 is a synthetic peptide antigen corresponding to a specific epitope of the human melanoma-associated antigen recognized by T cells. This high-purity biochemical is critical for immunological research and diagnostic assay development, serving as a precise tool for studying melanoma-specific immune responses. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on oncology, immunotherapy, and autoimmune disease studies.

Application

• Immunological Research: Used as a target antigen in studies of cytotoxic T lymphocyte (CTL) responses against melanoma.
• Diagnostic Development: A key component in the development and validation of ELISA, ELISPOT, and other immunoassays for detecting anti-melanoma antibodies or T-cell activity.
• Vaccine Research: Serves as a model antigen in preclinical studies for dendritic cell vaccines and other melanoma-specific immunotherapies.
• T-Cell Receptor (TCR) Analysis: Employed in flow cytometry and tetramer staining to identify and characterize Melan-A/Mart-1-specific T cell populations.
• Quality Control Standard: Acts as a reference standard in the production and quality control of related diagnostic kits and reagents.
• Autoimmunity Studies: Investigated in the context of vitiligo and other autoimmune conditions where melanocyte antigens are targeted.

Basic Information

Product Name	Melan-A/Mart-1
CAS No.	204060-45-7
Molecular Formula	C144H238N44O43S
Molecular Weight	3276.8 g/mol
Synonyms	MART-1 Antigen; MART-1 (26-35) Peptide; Melanoma Antigen Recognized by T-Cells 1; AAGIGILTV Peptide; HLA-A*0201-restricted MART-1 epitope; gp100 antigen; MART126-35; Antigen LB39-AA
EINECS	Contact for details

Quality Control

Every batch of Melan-A/Mart-1 is manufactured and analyzed under strict quality management systems. Identity, purity, and peptide content are verified using advanced analytical techniques including HPLC and mass spectrometry. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, lyophilized powder is recommended. The product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture absorption. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water, DMSO, or dilute acetic acid
Single Impurity (HPLC)	≤ 1.0%
Water Content (K.F.)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.