Description

Fmoc-L-β-Homoserine(Otbu) CAS NO 203854-51-7 is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of homoserine residues with orthogonal side-chain protection. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel peptide therapeutics, peptide hormones, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled assembly of complex peptide sequences.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: Facilitates the site-specific modification of peptides for diagnostic or targeting applications.
• Combinatorial Chemistry Libraries: Serves as a versatile scaffold for generating diverse peptide libraries for screening.
• Biochemical Research: Employed in studying protein structure-function relationships and enzyme-substrate interactions.
• Protecting Group Chemistry: Demonstrates the utility of Fmoc (9-fluorenylmethoxycarbonyl) and tert-butyl ester protecting groups in multi-step organic synthesis.

Basic Information

Product Name	Fmoc-L-β-Homoserine(Otbu)
CAS No.	203854-51-7
Molecular Formula	C24H27NO6
Molecular Weight	425.47 g/mol
Synonyms	Fmoc-Hse(OtBu)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-β-homoserine tert-butyl ester; Fmoc-L-β-Homoserine tert-butyl ester; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-(tert-butoxy)butanoic acid; Fmoc-L-Homoserine(OtBu)-OH; Fmoc-β-Hse(OtBu)-OH; N-Fmoc-L-β-homoserine tert-butyl ester; Fmoc-L-β-Homoserine(O-tert-butyl)
EINECS	Contact for details

Quality Control

Our Fmoc-L-β-Homoserine(Otbu) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.