Description

Fmoc-L-β-Homolysine(Boc) CAS NO 203854-47-1 is a protected, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over peptide chain length and side-chain functionality, enabling the creation of novel peptide-based therapeutics and biochemical tools. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic institutions focused on developing peptide drugs, diagnostic agents, and specialized research probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled, sequential assembly of complex peptides, particularly in Fmoc-based strategies.
• Peptidomimetic Drug Development: Used to incorporate a homologated lysine side chain into peptide backbones, altering pharmacokinetic properties and biological activity for novel drug candidates.
• Bioconjugation and Linker Chemistry: Serves as a precursor for creating specialized linkers or introducing unique functional handles onto peptides for labeling or immobilization.
• Research Biochemicals: Essential for synthesizing custom peptides used in structure-activity relationship (SAR) studies, enzyme substrate mapping, and receptor ligand design.
• Antibody-Drug Conjugate (ADC) Payload Synthesis: Can be employed in the construction of peptide-based linkers or payload components for targeted cancer therapies.

Basic Information

Product Name	Fmoc-L-β-Homolysine(Boc)
CAS No.	203854-47-1
Molecular Formula	C32H44N2O7
Molecular Weight	568.71 g/mol
Synonyms	Fmoc-β-Homo-Lys(Boc)-OH; Nα-Fmoc-Nε-Boc-L-β-homolysine; Nα-(9-Fluorenylmethoxycarbonyl)-Nε-(tert-butoxycarbonyl)-L-β-homolysine; Fmoc-Lys(Boc)-β-homo-OH; (2S)-6-[(tert-Butoxycarbonyl)amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid; Fmoc-HLys(Boc)-OH; Boc-Lys(Fmoc)-β-homo; Protected β-Homolysine derivative
EINECS	Contact for details

Quality Control

Our Fmoc-L-β-Homolysine(Boc) is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.