Description

D-Phenylalanine, 4-Fluoro-, Phenylmethyl Ester is a high-purity, non-natural amino acid derivative featuring a fluorine atom at the para position of the phenyl ring and a benzyl ester protecting group. This compound is a critical chiral building block in advanced pharmaceutical research and development, particularly for the synthesis of peptide-based drugs and enzyme inhibitors. It is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require enantiomerically pure intermediates to develop new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel peptide drugs and protease inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore fluorinated amino acid analogs for improved metabolic stability and bioavailability.
• Peptide Synthesis: Serves as a protected fluorinated amino acid derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Bioconjugation & Probe Development: Utilized in the creation of fluorinated probes for biochemical assays and imaging studies.
• Chemical Biology: Acts as a tool compound to study enzyme mechanisms and protein-ligand interactions where fluorine acts as an isostere.
• Fine Chemical Synthesis: An intermediate for the preparation of more complex fluorinated organic molecules and specialty chemicals.

Basic Information

Product Name	D-Phenylalanine, 4-Fluoro-, Phenylmethyl Ester
CAS No.	203732-76-7
Molecular Formula	C₁₆H₁₆FNO₂
Molecular Weight	273.30 g/mol
Synonyms	D-4-Fluorophenylalanine benzyl ester; (R)-2-Amino-3-(4-fluorophenyl)propanoic acid benzyl ester; Benzyl D-4-fluorophenylalaninate; D-p-Fluorophenylalanine benzyl ester; Fmoc-D-4-Fluorophenylalanine-OBzl precursor; Bzl-D-Phe(4-F)-OH; (R)-2-Benzyloxycarbonylamino-3-(4-fluorophenyl)propanoic acid (deprotected form reference)
EINECS	Contact for details

Quality Control

Our D-Phenylalanine, 4-Fluoro-, Phenylmethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and identity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.