Description

3-Trifluoromethoxyphenylacetic Acid is a high-value fluorinated aromatic building block characterized by its phenylacetic acid core substituted with a trifluoromethoxy group. This compound is essential for introducing the metabolically stable and lipophilic trifluoromethoxy pharmacophore into target molecules, significantly enhancing their biological activity and physicochemical properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group improves compound stability and efficacy.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Electronics: Employed in the development of novel organic semiconductors and electro-optical materials.
• Chemical Research: A versatile building block in organic synthesis for introducing fluorine-containing motifs into complex molecular architectures.
• Peptide Modification: Used to create non-natural amino acid analogs for peptide-based drug discovery.

Basic Information

Product Name	3-Trifluoromethoxyphenylacetic Acid
CAS No.	203302-97-0
Molecular Formula	C9H7F3O3
Molecular Weight	220.14 g/mol
Synonyms	2-(3-(Trifluoromethoxy)phenyl)acetic Acid; α-(3-Trifluoromethoxyphenyl)acetic Acid; 3-(Trifluoromethoxy)benzeneacetic Acid; m-Trifluoromethoxyphenylacetic Acid; 3-TFMOPAA; 2-[3-(Trifluoromethoxy)phenyl]ethanoic Acid
EINECS	Contact for details

Quality Control

Our 3-Trifluoromethoxyphenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.