Description

3,4,5-Trifluoroanisole is a high-purity fluorinated aromatic ether, a key building block in advanced organic synthesis. Its unique trifluoromethyl-substituted anisole structure makes it an essential intermediate for creating complex molecules with enhanced stability and specific electronic properties. This compound is particularly valuable for research and development in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients. Global manufacturers and R&D laboratories rely on this material for its consistent quality and critical role in developing next-generation fluorinated compounds.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of active pharmaceutical ingredients (APIs), particularly in creating fluorine-containing drug candidates for oncology and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Serves as a key precursor in the manufacture of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & Electronic Materials: Used in the synthesis of fluorinated liquid crystals and organic semiconductors for display technologies and electronic devices.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution to introduce the 3,4,5-trifluoroanisole moiety into more complex structures.
• Material Science Research: Utilized in developing novel polymers, coatings, and specialty materials with specific dielectric or surface properties.

Basic Information

Item	Details
Product Name	3,4,5-Trifluoroanisole
CAS No.	203245-17-4
Molecular Formula	C7H5F3O
Molecular Weight	162.11 g/mol
Synonyms	1,2,3-Trifluoro-5-methoxybenzene; 3,4,5-Trifluoromethoxybenzene; Anisole, 3,4,5-trifluoro-; 3,4,5-Trifluoro-1-methoxybenzene; Benzene, 1,2,3-trifluoro-5-methoxy-; Methoxytrifluorobenzene
EINECS	Contact for details

Quality Control

Every batch of 3,4,5-Trifluoroanisole is produced and tested under a strict quality management system. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. Our quality protocols are designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases. Due to its highly volatile nature, ensure containers are securely sealed. Recommended storage temperature is 2-8°C for long-term stability, though short-term storage at controlled room temperature (15-25°C) is acceptable.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Density (at 20°C)	~1.3 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.