Description

2,4-Difluoro-1-isopropoxybenzene is a high-purity fluorinated aromatic ether building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and the isopropoxy group, which are critical for modulating the electronic properties, lipophilicity, and metabolic stability of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro motif enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and stability.
• Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine into polymer backbones, enhancing chemical resistance, thermal stability, and lowering surface energy for coatings.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl and heteroaryl systems.
• Chemical Research: A versatile building block in academic and industrial research for exploring new fluorination methodologies and structure-activity relationships (SAR).

Basic Information

Product Name	2,4-Difluoro-1-Isopropoxybenzene
CAS No.	203059-83-0
Molecular Formula	C9H10F2O
Molecular Weight	172.17 g/mol
Synonyms	1-Isopropoxy-2,4-difluorobenzene; 2,4-Difluorophenyl Isopropyl Ether; Benzene, 2,4-difluoro-1-(1-methylethoxy)-; Isopropyl 2,4-Difluorophenyl Ether; (2,4-Difluorophenoxy)propane
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-1-isopropoxybenzene is manufactured and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency to meet the stringent requirements of process chemistry and scale-up. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.