Description

(S,S)-1,2-Bis(tert-Butylmethylphosphino)Ethane CAS NO 203000-53-7 is a high-purity, chiral bidentate phosphine ligand essential for advanced catalytic processes. Its primary value lies in enabling highly selective and efficient asymmetric hydrogenation and cross-coupling reactions, which are critical for producing enantiomerically pure compounds. This ligand is indispensable for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones in pharmaceutical intermediate synthesis.
• Cross-Coupling Reactions: Facilitates efficient C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Buchwald-Hartwig aminations, for complex molecule assembly.
• Homogeneous Catalyst Preparation: Used to synthesize well-defined transition metal complexes (e.g., with Rh, Ru, Pd) for specialized catalytic applications.
• Fine Chemical and Agrochemical Manufacturing: Enables the production of chiral active ingredients and advanced intermediates with high optical purity.
• Academic and Industrial R&D: A valuable tool for developing new synthetic methodologies and exploring novel catalytic cycles in laboratory settings.
• Process Chemistry Optimization: Employed to scale up and improve the efficiency and selectivity of existing catalytic routes in pilot plants and production.

Basic Information

Product Name	(S,S)-1,2-Bis(tert-Butylmethylphosphino)Ethane
CAS No.	203000-53-7
Molecular Formula	C₁₄H₃₂P₂
Molecular Weight	262.34 g/mol
Synonyms	(S,S)-Bis(tert-butylmethylphosphino)ethane; (S,S)-Bis(tert-butylmethylphosphanyl)ethane; (S,S)-1,2-Bis[(tert-butyl)methylphosphino]ethane; (S,S)-DTBMPE; (S,S)-t-Bu-Me-PE; (S,S)-Di-tert-butylmethylphosphinoethane; (S,S)-Ethane-1,2-diylbis(tert-butylmethylphosphane); (S,S)-Bis(tert-butylmethylphosphanyl)ethane
EINECS	Contact for details

Quality Control

Our (S,S)-1,2-Bis(tert-Butylmethylphosphino)Ethane is manufactured under strict quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot undergoes comprehensive analysis, including chiral HPLC, NMR, and elemental analysis. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This product is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use and handled in a controlled, dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.