Description

Nf 279 CAS NO 202983-32-2 is a high-purity, small molecule chemical compound widely recognized as a potent and selective inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome. This compound matters for researchers and developers in the life sciences sector as it provides a critical tool for modulating inflammatory pathways, which are implicated in a wide range of diseases. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on immunology, neurology, and metabolic disorder research.

Application

• Pharmacological Research: Used as a key reference standard and active agent in studies targeting NLRP3 inflammasome activity.
• Drug Discovery & Development: Serves as a lead compound or biochemical tool for screening and developing novel anti-inflammatory therapeutics.
• Academic & Institutional Research: Applied in in vitro and in vivo models to investigate the role of NLRP3 in diseases like Alzheimer's, arthritis, diabetes, and gout.
• Biomarker Studies: Utilized in assays to understand downstream effects of inflammasome inhibition on cytokine release (e.g., IL-1β).
• Preclinical Testing: Employed in animal models to validate efficacy and mechanism of action for potential drug candidates.
• Biochemical Pathway Analysis: A critical reagent for elucidating cellular signaling pathways related to innate immunity and pyroptosis.

Basic Information

Product Name	Nf 279
CAS No.	202983-32-2
Molecular Formula	C₁₉H₁₅N₃O₃S
Molecular Weight	365.41 g/mol
Synonyms	Nf279; NF-279; 8,8'-[Carbonylbis(imino-3,1-phenylenecarbonylimino)]bis(1,3,5-naphthalenetrisulfonic acid) hexasodium salt; Suramin hexasodium salt analog; NLRP3 Inflammasome Inhibitor NF279; P2X receptor antagonist; Reactive Blue 2 derivative; PPADS analog
EINECS	Contact for details

Quality Control

Our Nf 279 is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry for structural confirmation, and NMR for identity. A detailed Certificate of Analysis (COA) documenting all specifications and test results is provided with every shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For daily use, the product may be stored at 2-8°C for short periods. The container should be kept in a dry, cool, and well-ventilated area. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 1.0%
Solubility	Soluble in DMSO, Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.