Description

4-Chloro-3-Fluoroiodobenzene is a high-purity halogenated benzene derivative, a key building block in advanced organic synthesis. Its unique combination of chlorine, fluorine, and iodine substituents makes it a versatile intermediate for creating complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, leveraging its halogen pattern for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings, where the iodine acts as a superior leaving group.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry: A valuable starting material for further selective fluorination or functional group transformations in medicinal chemistry.

Basic Information

Product Name	4-Chloro-3-Fluoroiodobenzene
CAS No.	202982-67-0
Molecular Formula	C6H3ClFI
Molecular Weight	256.44 g/mol
Synonyms	1-Chloro-2-fluoro-4-iodobenzene; 4-Chloro-3-fluoro-1-iodobenzene; 2-Fluoro-4-iodochlorobenzene; 4-Iodo-1-chloro-2-fluorobenzene; Benzene, 1-chloro-2-fluoro-4-iodo-; (4-Chloro-3-fluorophenyl)iodide
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluoroiodobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.