Description

(R)-1-n-Boc-β-Proline is a high-purity, non-natural amino acid derivative widely used as a critical chiral building block in advanced organic synthesis. Its primary value lies in introducing a sterically defined, protected proline moiety into complex molecular architectures, enabling precise control over three-dimensional structure. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of peptide-based therapeutics, enzyme inhibitors, and novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), especially for peptidomimetics and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a conformationally constrained (R)-configured proline analog, influencing peptide backbone geometry and biological activity.
• Chemical Biology & Proteomics: Serves as a tool compound for studying protein-protein interactions and enzyme mechanisms where proline stereochemistry is crucial.
• Catalyst & Ligand Development: Employed in the synthesis of novel chiral catalysts and ligands for asymmetric synthesis.
• Academic & Industrial R&D: A fundamental reagent for medicinal chemistry programs focused on structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	(R)-1-n-Boc-β-Proline
CAS No.	202931-85-9
Molecular Formula	C10H17NO4
Molecular Weight	215.25 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic Acid; (R)-1-Boc-3-pyrrolidinecarboxylic Acid; (R)-1-(tert-Butyloxycarbonyl)-β-proline; (R)-N-Boc-3-pyrrolidinecarboxylic Acid; (R)-1-Boc-3-carboxypyrrolidine; (3R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic Acid; (R)-N-tert-Butoxycarbonyl-3-pyrrolidinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our (R)-1-n-Boc-β-Proline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research and cGMP applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.