Description

Conantokin R is a highly specific and potent peptide neurotoxin derived from cone snail venom, identified by CAS NO 202925-60-8. This compound is a critical research tool for studying N-methyl-D-aspartate (NMDA) receptor subtypes, particularly those containing the NR2B subunit, due to its selective antagonistic activity. It is essential for neuroscientists and pharmaceutical researchers investigating neurological pathways, excitotoxicity, and potential therapeutic targets for conditions like stroke, chronic pain, and neurodegenerative diseases.

Application

• Neuroscience Research: A selective antagonist for studying the structure, function, and pharmacology of NR2B-containing NMDA receptors in synaptic transmission and plasticity.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening and target validation for neurological disorders.
• Biochemical Assays: Employed in receptor binding studies, calcium flux assays, and electrophysiological experiments to characterize receptor inhibition.
• Toxicology Studies: Serves as a model compound for understanding the mechanisms of ion channel block by natural peptide toxins.
• Academic & Pharmaceutical R&D: Fundamental reagent for basic research and pre-clinical development of neuroprotective agents and analgesics.

Basic Information

Product Name	Conantokin R
CAS No.	202925-60-8
Molecular Formula	C96H147N31O27
Molecular Weight	2155.4 g/mol
Synonyms	Conantokin-R; Con-R; γ-carboxyglutamate-containing conantokin peptide; NMDA receptor antagonist conantokin R; Conantokin from Conus radiatus; Conantokin R (Conus radiatus); Peptide neurotoxin conantokin R
EINECS	Contact for details

Quality Control

Our Conantokin R is produced and handled under stringent quality protocols suitable for research applications. Each batch is characterized using advanced analytical techniques to ensure identity, purity, and biological activity. A comprehensive Certificate of Analysis (COA) is provided, detailing results for purity (HPLC), peptide content, amino acid analysis, and mass spectrometry. We adhere to ISO 9001 quality management principles to guarantee batch-to-batch consistency and supply reliability for your critical research needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity	Confirmed by functional assay (e.g., NMDA receptor inhibition)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.