Description

3-Chloro-4-Fluoroanisole is a versatile halogenated anisole derivative serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the anisole ring, makes it a valuable precursor for creating complex molecules with tailored properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a substituted anisole core.
• Agrochemical Synthesis: Used in the research and production of herbicides, fungicides, and insecticides, where the halogen atoms introduce specific bioactivity.
• Liquid Crystal & Electronic Chemicals: Acts as a starting material for the synthesis of fluorinated liquid crystal compounds and other specialty electronic materials.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce the methoxy-dihalo benzene moiety.
• Dye & Pigment Intermediate: Utilized in the production of specialized dyes and pigments where halogenated anisoles modify color and stability properties.
• Research & Development: Serves as a standard or reagent in academic and industrial R&D for exploring new chemical entities and reaction pathways.

Basic Information

Product Name	3-Chloro-4-Fluoroanisole
CAS No.	202925-07-3
Molecular Formula	C7H6ClFO
Molecular Weight	160.57 g/mol
Synonyms	1-Chloro-2-fluoro-4-methoxybenzene; 4-Methoxy-2-fluoro-1-chlorobenzene; 2-Fluoro-4-methoxychlorobenzene; 3-Chloro-4-fluoro-1-methoxybenzene; Anisole, 3-chloro-4-fluoro-; 3-Chloro-4-fluorophenyl methyl ether
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluoroanisole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the stringent requirements of our global clientele in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.