Description

4-Bromo-2,5-Difluoroanisole is a high-purity fluorinated and brominated aromatic ether, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique halogenated structure makes it an indispensable building block for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where its difluoro and bromo substituents contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Functional Material Research: Employed in academic and industrial R&D for creating novel polymers and ligands with specific electronic properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	4-Bromo-2,5-Difluoroanisole
CAS No.	202865-60-9
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	1-Bromo-4-methoxy-2,5-difluorobenzene; 2,5-Difluoro-4-bromoanisole; Benzene, 1-bromo-4-methoxy-2,5-difluoro-; Anisole, 4-bromo-2,5-difluoro-; 4-Bromo-2,5-difluoromethoxybenzene
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,5-Difluoroanisole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.