Description

2-Bromo-4,6-Difluoroanisole is a high-purity, multi-functional halogenated anisole derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce bromine and fluorine functionalities with precise regiocontrol.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the difluoroanisole moiety contributes to enhanced biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing aromatic cores essential in electronic materials for displays and lighting.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Functional Dye Chemistry: Employed in the synthesis of specialized fluorophores and chromophores for sensing and imaging applications.
• Chemical Research & Development: A versatile reagent for exploring new reaction pathways and synthesizing novel aromatic compounds in academic and industrial R&D labs.

Basic Information

Product Name	2-Bromo-4,6-Difluoroanisole
CAS No.	202865-59-6
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	1-Bromo-3,5-difluoro-2-methoxybenzene; 3,5-Difluoro-2-methoxybromobenzene; Benzene, 1-bromo-3,5-difluoro-2-methoxy-; 2-Methoxy-3,5-difluorobromobenzene; Anisole, 2-bromo-4,6-difluoro-; 4,6-Difluoro-2-bromoanisole
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4,6-Difluoroanisole is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.