Description

2-Bromo-4,5-Difluoroanisole is a versatile fluorinated anisole derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of bromine and fluorine substituents on the aromatic ring, which enables precise structural modifications and introduces desirable electronic properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated or halogenated aromatic systems for enhanced bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the difluoroanisole core contributes to product efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), influencing charge transport and emission properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitutions, leveraging the reactive bromine site for further functionalization.
• Chemical Research & Development: Essential for academic and industrial R&D focused on exploring new fluorinated compounds and their unique physicochemical behaviors.

Basic Information

Product Name	2-Bromo-4,5-Difluoroanisole
CAS No.	202865-58-5
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	1-Bromo-2,3-difluoro-4-methoxybenzene; Benzene, 1-bromo-2,3-difluoro-4-methoxy-; 2,3-Difluoro-4-methoxybromobenzene; 4-Methoxy-2,3-difluorobromobenzene; Anisole, 2-bromo-4,5-difluoro-; 2-Bromo-4,5-difluoromethoxybenzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-4,5-Difluoroanisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.