Description

1-Bromo-2,5-Dichloro-3-Fluorobenzene is a high-purity halogenated benzene derivative, serving as a critical building block in advanced chemical synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecules with specific electronic and steric properties. This compound is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly for candidates containing halogenated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its ability to modify electronic properties.
• Cross-Coupling Reactions: Serves as a versatile substrate in palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations for creating complex biaryl structures.
• Chemical Research & Development: An essential reagent for medicinal chemistry programs and process chemistry optimization in contract research and manufacturing organizations (CROs/CMOs).
• Dye and Pigment Intermediate: Used in the synthesis of specialized halogenated dyes and pigments for high-performance applications.

Basic Information

Product Name	1-Bromo-2,5-Dichloro-3-Fluorobenzene
CAS No.	202865-57-4
Molecular Formula	C6H2BrCl2F
Molecular Weight	243.89 g/mol
Synonyms	2-Bromo-1,4-Dichloro-5-Fluorobenzene; 3-Fluoro-1-bromo-2,5-dichlorobenzene; Benzene, 1-bromo-2,5-dichloro-3-fluoro-; 2,5-Dichloro-3-fluorobromobenzene; 5-Bromo-2,4-dichlorofluorobenzene; 1-Bromo-2,5-dichloro-3-fluorobenzene; Bromodichlorofluorobenzene (mixed isomer designation)
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,5-Dichloro-3-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent identity. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring reliable and traceable raw materials for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.