Description

Benztropine Mesylate (n-Methyl-D3, 98%) 95% Chemical Purity is a deuterated analog of the anticholinergic pharmaceutical compound benztropine mesylate, where three hydrogen atoms on the methyl group are replaced with deuterium. This high-purity, isotopically labeled standard is critical for ensuring accuracy and reliability in quantitative analytical methods, particularly in pharmaceutical research and development. It is primarily used by researchers and quality control laboratories in the pharmaceutical, contract research organization (CRO), and analytical chemistry sectors for applications such as internal standard preparation, method development, and metabolism studies.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, non-interfering internal standard for the precise quantification of benztropine and its metabolites in complex biological matrices like plasma and urine.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracing and measurement of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Pharmaceutical Method Development and Validation: Used as a reference material to develop, optimize, and validate robust analytical methods, ensuring regulatory compliance (e.g., FDA, ICH guidelines).
• Drug Impurity Profiling and Characterization: Assists in the identification and quantification of process-related impurities and degradation products during drug substance manufacturing.
• Forensic and Toxicology Analysis: Provides a reliable standard for the confirmatory analysis of benztropine in forensic toxicology screenings.
• Stable Isotope Labeling Research: Used in mechanistic studies to investigate metabolic pathways and the stability of molecular fragments.

Basic Information

Item	Detail
Product Name	Benztropine Mesylate (n-Methyl-D3, 98%) 95% Chemical Purity
CAS No.	202529-16-6
Molecular Formula	C21H22D3NO•CH4O3S
Molecular Weight	403.55 g/mol (approximate)
Synonyms	Benztropine Mesylate-d3; 3α-(Diphenylmethoxy)-1αH,5αH-tropane-d3 Methanesulfonate; 1H,5H-Tropan-3α-ol (phenylcyclopentyl)acetate-d3 Methanesulfonate; Benztropine-d3 Mesylate; (3-endo)-3-(Diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane-d3 Methanesulfonate; Deuterated Benztropine Mesylate; n-Methyl-D3 Benztropine Mesylate; Cogentin-d3 (labeled analog)
EINECS	Contact for details

Quality Control

Our Benztropine Mesylate (n-Methyl-D3, 98%) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the specified 95% chemical purity and 98% isotopic enrichment (n-Methyl-D3). Standard testing includes identification (IR, NMR), assay (HPLC), and determination of isotopic purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Enrichment (n-Methyl-D3)	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.