Description

Caffeine(3-Methyl-13C) is a stable isotope-labeled analog of caffeine, where the methyl group at the 3-position is enriched with the carbon-13 isotope. This precise labeling is critical for advanced analytical and research applications, providing an internal standard for accurate quantification and metabolic pathway tracing. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, nutraceutical, and forensic science industries who require the highest level of analytical precision.

Application

• Internal Standard for Quantitative Analysis: Used in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the precise measurement of caffeine levels in complex matrices.
• Metabolic Pathway Studies: Enables the tracing of caffeine and its metabolites in pharmacokinetic, pharmacodynamic, and clinical research studies.
• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for method development, validation, and quality control in drug manufacturing.
• Forensic and Doping Control Analysis: Provides definitive identification and quantification of caffeine in forensic toxicology and anti-doping programs.
• Nutritional and Clinical Research: Used in studies investigating caffeine absorption, distribution, and effects in dietary supplements and medical foods.
• Environmental Analysis: Acts as a tracer in studies monitoring caffeine as a biomarker for wastewater contamination and environmental impact.

Basic Information

Product Name	Caffeine(3-Methyl-13C)
CAS No.	202282-98-2
Molecular Formula	C713CH10N4O2
Molecular Weight	195.19 g/mol (for 13C1 labeled form)
Synonyms	1,3,7-Trimethyl-3-(13C)methylxanthine; Caffeine-3-13C-methyl; [3-13C]Caffeine; Caffeine (methyl-13C); 3-Methyl-13C Caffeine; 1,3,7-Trimethyl-2,6-dioxopurine-3-(13C)methyl; Theine-3-(13C)methyl; Guaranine-3-(13C)methyl
EINECS	Contact for details

Quality Control

Every batch of Caffeine(3-Methyl-13C) is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic purity (atom % 13C), chemical purity (by HPLC), and confirmatory identity testing. Our quality commitment ensures the material meets the stringent requirements for use as a high-grade reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	13C labeled position confirmed
Assay (HPLC)	≥98.0% (chemical purity)
Isotopic Purity	≥99 atom % 13C
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.