Description

Z-Gly-Gly-Phe-βna CAS NO 202001-87-4 is a synthetic, protected tripeptide derivative featuring a benzylamide (βna) C-terminus and a benzyloxycarbonyl (Z) N-terminal protecting group. This compound serves as a crucial building block and intermediate in advanced peptide synthesis and medicinal chemistry research. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and academic laboratories for developing novel therapeutic agents and studying enzyme-substrate interactions.

Application

• Pharmaceutical Intermediate: Key building block for the solid-phase and solution-phase synthesis of complex peptide-based drug candidates.
• Protease Substrate Analog: Used in biochemical assays to study the specificity and inhibition of proteolytic enzymes like chymotrypsin and subtilisin.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize peptide drug potency and stability.
• Bioconjugation: The reactive termini allow for conjugation to other molecules, carriers, or surfaces for creating targeted delivery systems.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Chemical Biology Tool: Utilized in probing biological pathways and protein-protein interactions due to its specific peptide sequence.

Basic Information

Item	Details
Product Name	Z-Gly-Gly-Phe-βna
CAS No.	202001-87-4
Molecular Formula	C28H28N4O6
Molecular Weight	516.55 g/mol
Synonyms	Z-Gly-Gly-Phe-NH-Benzyl; N-Benzyloxycarbonyl-glycyl-glycyl-L-phenylalaninamide; Benzyl N-[(benzylamino)carbonyl]-N-[2-[[(1S)-1-benzyl-2-(benzylamino)-2-oxoethyl]amino]-2-oxoethyl]glycinate; CBZ-Gly-Gly-Phe-NH-Bzl; Z-GGF-NH-Bn; Nα-CBZ-Gly-Gly-L-Phe-benzylamide; Benzyl (2S)-2-[[2-(2-[[2-(benzyloxycarbonylamino)acetyl]amino)acetyl]amino)-3-phenylpropanoyl]amino]acetate
EINECS	Contact for details

Quality Control

Our Z-Gly-Gly-Phe-βna is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS and NMR for structural confirmation, and chiral analysis to ensure enantiomeric purity. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.