Description

Z-Gly-Ala-Met-Amc CAS NO 201928-39-4 is a specialized fluorogenic peptide substrate designed for sensitive protease activity assays. This compound is of critical importance in biochemical research and pharmaceutical development for the precise detection and quantification of specific enzymatic activity. It is primarily needed by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in protease inhibitor screening and enzyme mechanism studies.

Application

• Protease Activity Assays: As a fluorogenic substrate for monitoring the activity of specific proteases in real-time kinetic studies.
• High-Throughput Screening (HTS): Used in drug discovery platforms to identify and characterize novel protease inhibitors.
• Enzyme Kinetic Studies: Essential for determining kinetic parameters (Km, Vmax, kcat) of target proteases.
• Diagnostic Development: A key component in developing fluorometric diagnostic tests for diseases linked to abnormal protease activity.
• Biochemical Research: For studying protease function, regulation, and substrate specificity in purified systems or cell lysates.
• Quality Control in Biologics: Monitoring protease activity during the production and purification of therapeutic proteins.

Basic Information

Product Name	Z-Gly-Ala-Met-Amc
CAS No.	201928-39-4
Molecular Formula	C22H30N4O7S
Molecular Weight	494.56 g/mol
Synonyms	Z-Gly-Ala-Met-AMC; Benzyloxycarbonyl-Gly-Ala-Methionine 7-Amido-4-methylcoumarin; Z-Gly-Ala-Met-7-amido-4-methylcoumarin; CBZ-Gly-Ala-Met-AMC; N-CBZ-Glycyl-L-alanyl-L-methionine 7-amido-4-methylcoumarin; Fluorogenic Substrate for Proteases; Protease Substrate Z-GAM-AMC
EINECS	Contact for details

Quality Control

Our Z-Gly-Ala-Met-Amc is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and identity confirmation by mass spectrometry, to ensure it meets the high standards required for sensitive research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.