Description

H-Cit-Amc Tfa CAS NO 201851-46-9 is a specialized protected amino acid derivative, specifically the trifluoroacetate salt of the Fmoc-protected citrulline amino acid. This compound is a critical building block in modern solid-phase peptide synthesis (SPPS), enabling the controlled and efficient incorporation of the unique amino acid citrulline into peptide chains. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who are developing peptide-based therapeutics, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary reagent for the automated or manual synthesis of peptides containing citrulline residues.
• Pharmaceutical Research & Development: Key intermediate in the production of peptide drug candidates targeting autoimmune diseases, cancer, and inflammatory conditions.
• Bioconjugation & Protein Engineering: Used to introduce citrulline sites for site-specific modifications, labeling, or to study post-translational modifications like citrullination.
• Antibody & Epitope Mapping: Crucial for synthesizing citrullinated peptide antigens used in immunoassays and for studying rheumatoid arthritis biomarkers.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies related to peptidylarginine deiminases (PADs).
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening of bioactive peptides.

Basic Information

Product Name	H-Cit-Amc Tfa
CAS No.	201851-46-9
Molecular Formula	C₂₆H₂₉F₃N₄O₇
Molecular Weight	566.53 g/mol
Synonyms	Fmoc-Cit-OH•TFA; N-α-Fmoc-N-δ-CBZ-L-citrulline trifluoroacetate salt; Fmoc-Citrulline(CBZ)-OH TFA salt; Fmoc-L-citrulline(Cbz)-OH•TFA; N-α-(9-Fluorenylmethoxycarbonyl)-N-δ-(benzyloxycarbonyl)-L-citrulline trifluoroacetate; Fmoc-Cit(CBZ)-OH•TFA; (2S)-5-[(Benzyloxycarbonyl)amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid trifluoroacetate
EINECS	Contact for details

Quality Control

Our H-Cit-Amc Tfa is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive synthetic applications. Each batch is analyzed via HPLC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles for active pharmaceutical ingredient (API) intermediates where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.